Publications Related the Gastro-Intestinal Physiology-Mechanics and Peristalsis

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• Brasseur, JG., Ulerich, R, Dai, Q, Patel, D, Soliman, A, Miller, LS. 2007 Pharmacological separation of the gastro-esophageal segment into three sphincteric components. J Physiology 580: 961-975. full pdf
• Pal, A., Brasseur, J.G., Abrahamsson, B. 2007 A Magenstrasse for gastric emptying. J. Biomechanics 40: 12-2-1210. full pdf
• Brasseur, JG, Nicosia, MA, Pal, A, Miller, LS. 2007 Function of longitudinal vs. circular muscle fibers in esophageal peristalsis, deduced with mathematical modeling. World J. Gastroenterol. 13: 1335-1346. full pdf
• Ghosh, S., Janiak, P., Schwizer, W., Hebbard, G. S., Brasseur, J.G. 2006 Physiology of the esophageal pressure transition zone: Separate contraction waves above and below. Amer. J. Physiol. 290: 568-576. full pdf.
• Miller, LS, Dai, Q, Korimilli, A, Levitt, B, Ramzan, Z, Brasseur, JG. 2006 Use of endoluminal ultrasound to evaluate gastrointestinal motility. Dig Dis. 24: 319-341. full pdf
• Kwiatek, M.A., Steingoetter, A., Pal, A., Menne, D., Brasseur, J.G., Hebbard, G., Boesiger, P., Thumshirn, M., Fried, M. Schwizer, W. 2006 Quantification of distal antral contractile motility in healthy human stomach with magnetic resonance imaging. J Magnetic Resonance Imaging 24: 1101-1109. full pdf
• Dai, Q., Korimilli, A., Thangada, V.K., Chung, C.Y., Parkman, H., Brasseur, J.G., Miller, L.S. 2006 Muscle shortening along the normal esophagus during swallowing. Digestive Diseases and Sciences 51: 105-109. full pdf
• Abrahamsson B, Pal A, Sjoberg M, Carlsson M, Laurell E, Brasseur JG. 2005 A novel in-vitro and numerical analysis of shear-induced dissolution from tablets in the fed stomach. Pharmaceutical Research 22: 1215-1226. full pdf
• Ghosh, S.K., Kahrilas, P.J., Zaki, T, Pandolfino, J.E., Joehl, R.J., Brasseur, J.G. 2005 The mechanical basis of impaired esophageal emptying post fundoplication. In press, Amer. J. Physiol.   full pdf
• Ghosh, Sudip. 2005 Modeling, Mechanics and Physiology of the Esophagus and Lower Sphincter. Ph.D. Thesis, Department of Mechanical Engineering, The Pennsylvania State University, University Park, PA.   full pdf
• Pal, A., Indireshkumar, K., Schwizer, W., Abrahamsson, B., Fried, M., Brasseur, J.G. 2004 Gastric flow and mixing studied using computer simulation.  Proc. Royal Soc. London: Biological Sciences 271: 2587-2594.   full pdf
• Pandolfino, J.E., Shi, Zhang, Q., Ghosh, S., Brasseur, J.G., Kahrilas, P.J. 2004 Measuring EGJ opening patterns using high resolution intraluminal impedance. Neurogastroenterol Motil. 16: 1-7.   full pdf
• Schiffner, Bryan J. 2004 Opening Stiffness of the Esophago-gastric Segment in Health, with GERD, and after Endoscopic Surgery. M.S. Thesis, Department of Mechanical Engineering, The Pennsylvania State University, University Park, PA.  full pdf
• Fox, M., Hebbard, G., Janiak, P., Brasseur, J.G., Ghosh, S., Thumshirn, M., Fried, M., Schwizer, W. 2004 High resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry. Neurogastroenterol. Motil . 16: 533-542. full pdf
• Miller, Larry S., Kim, Joseph K., Dai, Qing, Brasseur, J.G. 2004 The mechanics and hemodynamics of esophageal varices during peristaltic contraction. Amer. J. Physiol. 287: G830-G835.   full pdf
• Pal, A., Williams, R.B., Cook, I.J, Brasseur, J.G.. 2003 Intrabolus pressure gradient identifies pathological constriction in the upper esophageal sphincter during flow. Am. J. Physiol. 285: G1037-G1048.   full pdf
• Dai, Q, Liu, J-B, Brasseur, JG, Thangada, VK, Thomas, B, Parkman, H, Miller, LS 2003 Volume (3-dimensional) space-time reconstruction of esophageal peristaltic contraction by using simultaneous US and manometry. Gastrointestinal Endoscopy 58: 913-919. full pdf
• Ulerich, Rhys 2003, Anatomical and Physiological Structure of the Esophago-Gastric Segment. Shreyers Honors College Undergraduate Thesis, Department of Mechanical Engineering, The Pennsylvania State University.   full pdf
• Guilinger, Scott 2003 Subtle Muscle Behavior in the Esophagus during Swallowing. Shreyers Honors College Undergraduate Thesis, Department of Mechanical Engineering, The Pennsylvania State University.   full pdf
• Nicosia, M.A., Brasseur, J.G. 2002 A Model for estimating muscle tension in vivo during esophageal bolus transport. J. Theor. Biol.  219 : 235 - 255. full pdf
• Shi, G., Pandolfino, J., Joehl, R.J., Brasseur, J.G., Kahrilas, P.J. 2002 Distinct patterns of esophageal shortening during primary peristalsis, secondary peristalsis and transient lower esophageal sphincter relaxation. Neurogastroenterology & Motility 14 : 505-512. full pdf
• Pandolfino, J.E., Shi, G., Curry, J., Joehl, R.J., Brasseur, J.G., Kahrilas, P.J. 2002 Esophagogastric junction distensibility: a factor contributing to sphincter incompetence. Amer. J. Physiol. 282: G1052-G1058. full pdf
• Pal., A. Brasseur, J.G. 2002 The mechanical advantage of local longitudinal shortening of the human esophagus. J. Biomechanical Eng. 142 : 94-100. full pdf
• Williams, R.B., Pal, A., Brasseur, J.G., Cook, I.J. 2001 Space-time pressure structure of the pharyngo-esophageal segment during swallowing.  Am. J. Physiol. 281: G1290-G1300. full pdf
• Nicosia, M.A., Brasseur, J.G., Liu, J-L., Miller, L.S. 2001 Longitudinal shortening in the human esophagus from high-frequency ultrasonography. Amer. J. Physiol. 281: G1022-G1033. full pdf
• Faas, H., Hebbard, G.S., Feinle C., Kunz, P., Brasseur, J.G., Indireshkumar, K., Dent, J., Boesiger, P., Thumshirn, M., Fried, M., Schwizer, W. 2001 Pressure-geometry relationship in the antroduodenal region during slowed and enhanced gastric emptying. Amer. J. Physiol 281 : G1214-G1220. full pdf
• Pal, A. 2000 Motility of the Pharynx Analyzed Using Lattice Boltzmann Simulation. Ph.D Thesis, Department of Mechanical Engineering, The Pennsylvania State University. full pdf
• Tatum, R.P., Shi, G., Manka, M.A., Brasseur, J.G., Joehl, R.J., Kharilas, P.K. 2000 Bolus transit assessed by an esophageal stress test in postfundoplication dysphagia. J. Surgical Research 91 : 56-60. full pdf
• Bardan, E., Xie, P., Brasseur, J.G., Dua, K., Ulualp, S.O., Kern, M., Shaker, R. 2000 Effect of aging on the upper and lower esophageal sphincters. Eur. J. Gastroenterol. and Heptatol. 12 : 1221-1225. full pdf
• Indireshkumar, K., Brasseur, J.G., Faas, H., Hebbard, G.S., Kunz, P., Dent, J., Boesinger, P., Feinle, C., Fried, M., Li, M., Schwizer, W. 2000 Relative contributions of “pressure pump” and “peristaltic pump” to slowed gastric emptying, Amer. J. Physiol. 278: G604-G616. full pdf
• Kahrilas, P.J., Lin, S., Spiess, A.E., Brasseur, J.G., Joehl, R.J., Manka, M. 1998 The impact of fundoplication on bolus transit across the gastroesophageal junction. Amer. J. Physiol. 275 : G1386-G1393. full pdf
• Wu, S.J., Shung, K.K., Brasseur, J.G. 1998 In situ measurement of doppler power vs. flow turbulence intensity in red cell suspensions. Ultrasound in Medi.and Biol. 24: 1009-1021.   full pdf
• Lin, S., Brasseur, J.G., Pouderoux, P., Kahrilas, P.J. 1995  The phrenic ampulla:  distal esophagus or potential hiatal hernia?  Amer. J. Physiol. 268: G320-G327.   full pdf
• Li, M., Brasseur, J.G., Dodds, W.J. 1994 Analysis of normal and abnormal esophageal transport using computer simulation.  Amer. J. Phys. 266: G525-G543. full pdf
• Ren, J., Massey, B.T., Dodds, W.J., Kern, M.K., Brasseur, J.G., Shaker, R., Harrington, S. S. Hogan, W.J., Arndorfer, R.C. 1993. Determinants of intrabolus pressure during esophageal peristaltic bolus transport.  Amer. J. Physiol. 264: G407-G413. full pdf
• Li, M., Brasseur, J.G.  1993 Nonsteady peristaltic transport in finite length tubes.  J. Fluid Mech. 248 : 129-151. full pdf
• Brasseur, J.G.  1993  Mechanical studies of the esophageal function. Dysphagia 8: 384-386.
• Li, M., Brasseur, J.G., Kern, M.K., Dodds, W.J.  1992 Viscosity measurements of barium-sulfate mixtures for use in motility studies of the pharynx and esophagus.  Dysphagia 7: 17-30.  Reprinted by Brookfield Engineering Laboratories as publication AR-109.
• Brasseur, J.G., Dodds, W.J.  1991 Interpretation of intraluminal manometric measurements in terms of swallowing mechanics.  Dysphagia 6: 100-119. full pdf
• Ren, J., Dodds, W.J., Martin, C.J., Dantas, R.O., Mittal, R., Kern, M.K., Brasseur, J.G.  1991 Effect of increased intraabdominal pressure on peristalsis in the feline esophagus.  Amer. J. Physiol. 261: G417-G425. full pdf
• Massey, B.T., Dodds, W.J., Hogan, W.J., Brasseur, J.G., Helm, J.F.  1991 Abnormal esophageal motility:  an analysis of concurrent radiographic and manometric findings. Gastroenterology 101 : 344-354.
• Dantas, R.O., Kern, M.K., Massey, B.T., Dodds, W.J., Kahrilas, M.D., Brasseur, J.G., Cook, I.J, Lang, I.M. 1990  Effect of swallowed bolus variables on the oral and pharyngeal phases of swallowing.  Amer. J. Physiol. 258:  G675-G681. full pdf
• Dantas, R.O., Cook, I.J., Dodds, W.J., Kern, M.K., Lang, I.M., Brasseur, J.G.  1990 Biomechanics of cricopharyngeal bars.  Gastroenterology 99: 1269-1274.
• Cook, I.J., Dodds, W.J., Dantas, R.O., Massey, B., Kern, M.K., Lang, I.M., Brasseur, J.G., Hogan, W.J. 1989  Opening mechanism of the upper esophageal sphincter. Amer. J. Physiol. 257 : G748-G759. full pdf
• Brasseur, J.G., Corrsin, S., Lu, N.Q.  1987 The influence of a peripheral layer of different viscosity on peristaltic pumping with Newtonian fluids.  J. Fluid Mech. 174: 495-519. full pdf