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    CompBio Group

    Penn State University

    Computational Biomechanics: Research, Development & Application.

    PSU CompBio Lab

About Us

The Computational Biomechanics (CompBio) Group at Penn State University’s College of Engineering is focused on understanding the mechanics and physics of biological systems using computational methods. Research can be partitioned into three broad areas: 1) multiphysics, multiscale computational mechanics and methods, 2) problems at the interface of biology and multiscale mechanics, and 3) humans in extreme environments.

3 areas

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    Our Team

    Interdisciplinary Expertise in Engineering, Computational Mechanics and Biomechanics

    Reuben Kraft, Ph.D.
    Assistant Professor, Head of CompBio Laboratory

    Toma Marinov
    Post-Doctoral Scholar

    Chanyoung Lee
    Ph.D. Candidate

    Zacarie Hertel
    Ph.D. Candidate

    Vikram Subramani
    Ph.D. Candidate

    Jesse Gerber
    Master's Candidate

    Patricia Yvette De Tomas Medina
    Schreyer's Undergraduate Honors Student

    50

    Publications

    6,000

    Processor Cluster

    7

    Researchers

    8

    Active Projects

    Model Everything

    Anonymous

    Facilities

    Top-notch instruments and devices for the design, development, integration and testing for extreme environments.

    High Performance Computing
    Advanced Cyberinfrastructure

    We use massively parallel computing systems provided through Penn State's Institute for Cyberscience to create predictive models.

    Combined Computational & Experimental Workspaces
    Blended Teams for Better Research

    We share lab space with Dr. Daniel Cortes, an expert at experimental biomechanics, so collaborations with his team help us form a well-rounded view of problems.

    Lab Facilities
    Dry and Wet Lab Facilities

    From high-strain rate testing to cellular microscopy our facilities at Penn State are world-class. We frequently use magnetic resonance imaging, diffusion tensor imaging, nano-CT scanner, high Field MRI Facility.

    All
    Computing Lab
    High Performance Clusters
    Wet Lab
    Drop Tower
    Imaging
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    Publications


    Journal Papers

    • Garimella, H. T. (Supervised Student Author - Graduate Student), & Kraft, R. H. (2016). Modeling the mechanics of axonal fiber tracts using the embedded finite element method. International Journal for Numerical Methods in Biomedical Engineering(e02823), 1–21. ISBN/ISSN #/Case #/DOI #: doi: 10.1002/cnm.2796 (PDF)
    • Fielding, R. A. (Supervised Student Author - Graduate Student), Przekwas, A. J., Tan, X. G., & Kraft, R. H. (2015). Development of a lower extremity model for high strain rate impact loading. International Journal of Experimental and Computational Biomechanics, 3(2), 161-186. (PDF)
    • Lee, C. X. (Supervised Student Author - Graduate Student), Richtsmeier, J. T., & Kraft, R. H. (2015). A Computational Analysis of Bone Formation in the Cranial Vault in the Mouse. Frontiers in Bioengineering and Biotechnology, 3(24). http://journal.frontiersin.org/article/10.3389/fbioe.2015.00024. (PDF)
    • Swab, J. J., Tice, J., Wereszczak, A. A., & Kraft, R. H. (2014). Fracture toughness of advanced structural ceramics: Applying ASTM C1421. Journal of the American Ceramic Society, pp. 1-9. http://dx.doi.org/10.1111/jace.13293. ISBN/ISSN #/Case #/DOI #: 1551-2916 (PDF)
    • Clayton, J. D., Kraft, R. H., & Leavy, R. B. (2012). Mesoscale modeling of nonlinear elasticity and fracture in ceramic polycrystals under dynamic shear and compression. Journal of Solids and Structures, 49(18), 6. http://doi:10.1016/j.ijsolstr.2012.05.035. (PDF)
    • Kraft, R. H., Mckee, P. J., Dagro, A. M., & Grafton, S. T. (2012). Combining the finite element method with structural connectome-based analysis for modeling neurotrauma: Connectome neurotrauma mechanics. PLoS Computational Biology, 8(8), e1002619. http://dx.doi.org/10.1371%2Fjournal.pcbi.1002619. (PDF)
    • Kraft, R. H., & Molinari, J. F. (2008). A statistical investigation of the effects of grain boundary properties on transgranular fracture. Acta Materialia, 56(17), 10. http://doi:10.1016/j.actamat.2008.05.036. (PDF)
    • Kraft, R. H., Molinari, J. F., Ramesh, K. T., & Warner, D. W. (2008). Computational micromechanics of dynamic compressive loading of a brittle polycrystalline material using a distribution of grain boundary properties. The Journal of Mechanics and Physics of Solids, 56, 23. http://doi:10.1016/j.jmps.2008.03.009. (PDF)

    Conference Papers

    • Lee, C. (Supervised Student Author), & Kraft, R. H. (2016). A coupled reaction-diffusion-strain model for bone growth in the cranial vault. Proceedings of the 2016 Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C2016). http://archive.sb3c.org. (PDF)
    • Ranslow, A. N. (Supervised Student Author), & Kraft, R. H. (2016). The development of a “fuzzy” yield envelope for trabecular porcine skull bone using numerical simulations. Proceedings of the 2016 Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C2016). http://archive.sb3c.org. (PDF)
    • Motiwale, S. (Supervised Student Author - Graduate Student), Eppler, W., Hollingsworth, D., Hollingsworth, C., Morgenthau, J., & Kraft, R. H. (2016). Application of Neural Networks for Filtering Non-Impact Transients Recorded from Biomechanical Sensors. Proceedings of the IEEE International Conference on Biomedical and Health Informatics. (pp. 204 - 207). IEEE. http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=7455870&tag=1. ISBN/ISSN #/Case #/DOI #: 10.1109/BHI.2016.7455870 (PDF)
    • Reddy, S. N. (Supervised Student Author - Graduate Student), Fielding, R. A. (Supervised Student Author - Graduate Student), Robinson, M. J. (Supervised Student Author - Undergraduate Student), & Kraft, R. H. (2015). A computational study of fracture in the calcaneus under variable impact conditions. Volume 3: Biomedical and Biotechnology Engineering, (pp. pp. V003T03A058; 10 pages). American Society of Mechanical Engineers Congress and Explosion. http://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleID=2500554. ISBN/ISSN #/Case #/DOI #: doi:10.1115/IMECE2015-51984 (PDF)
    • Ranslow, A. N. (Supervised Student Author - Graduate Student), Kraft, R. H., Shannon, R. (Supervised Student Author - Undergraduate Student), De Tomas-Medina, P. (Supervised Student Author - Undergraduate Student), Radovitsky, R., Jean, A., Hautefeuille, M. P., Fagan, B., Ziegler, K. A., Weerasooriya, T., Dileonardi, A. M., Gunnarsson, A., & Satapathy, S. Microstructural analysis of porcine skull bone subjected to impact loading. Volume 3: Biomedical and Biotechnology Engineering, (pp. pp. V003T03A057; 10 pages). American Society of Mechanical Engineers Congress and Explosion. http://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleID=2500553. ISBN/ISSN #/Case #/DOI #: doi:10.1115/IMECE2015-51979 (PDF)
    • Garimella, H. T. (Supervised Student Author - Graduate Student), Yaun, H. (Supervised Student Author - Undergraduate Student), Johnson, B. D., Slobounov, S., & Kraft, R. H. (2015). Anisotropic constitutive model of human brain with intravoxel heterogeneity of fiber orientation using diffusion spectrum imaging (DSI). Volume 3: Biomedical and Biotechnology Engineering, (pp. pp. V003T03A011; 9 pages). Proceedings of the 2014 American Society of Mechanical Engineers Congress and Exposition. http://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleID=2204628. ISBN/ISSN #/Case #/DOI #: doi:10.1115/IMECE2014-39107 (PDF)
    • Fielding, R. A. (Supervised Student Author - Graduate Student), Tan, X. G., Przekwas, A. J., Kozuch, C. D. (Supervised Student Author - Undergraduate Student), & Kraft, R. H. (2015). High rate impact to the human calcaneus: A micromechanical analysis. Volume 3: Biomedical and Biotechnology Engineering, (pp. V003T03A009, (8 pages)). American Society of Mechanical Engineers Congress and Explosion. http://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleid=2204626. ISBN/ISSN #/Case #/DOI #: ISBN: 978-0-7918-4646-9 (PDF)
    • Kraft, R. H., & Garimella, H. T. (Supervised Student Author - Graduate Student) Embedded finite elements for modeling traumatic axonal injury. Proceedings of the Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C 2015). American Society of Mechanical Engineers. http://2015.sb3c.org/. (PDF)
    • Makwana, A. R. (Supervised Student Author - Graduate Student), Krishna, A. R. (Supervised Student Author - Graduate Student), Yuan, H. (Supervised Student Author - Undergraduate Student), Kraft, R. H., Zhou, X., Przekwas, A. J., & Whitley, P. (2014). Towards a micromechanical model of intervertebral disc degeneration under cyclic loading.(IMECE2014-39174), (pp. pp. V003T03A012; 7 pages). American Society of Mechanical Engineers Congress and Explosion. http://proceedings.asmedigitalcollection.asme.org/ConferenceProceedings.aspx. ISBN/ISSN #/Case #/DOI #: doi:10.1115/IMECE2014-39174 (PDF)
    • Lee, C. (Supervised Student Author - Graduate Student), Richtsmeier, J. T., & Kraft, R. H. (2014). A multiscale computational model for the growth of the cranial vault in craniosynostosis.(IMECE2014-38728), (pp. pp. V009T12A061; 6 pages). American Society of Mechanical Engineers Congress and Explosion. http://proceedings.asmedigitalcollection.asme.org/proceeding.aspx?articleID=2205491. ISBN/ISSN #/Case #/DOI #: doi:10.1115/IMECE2014-38728 (PDF)

    Conference Papers, Continued...

    • Fielding, R. A. (Supervised Student Author - Graduate Student), Kraft, R. H., Ryan, T. M., & Stecko, T. D. (2014). A micromechanics-based simulation of calcaneus fracture and fragmentation due to impact loading. 11th World Congress on Computational Mechanics (WCCM XI) 5th. European Conference on Computational Mechanics (ECCM V) 6th. European Conference on Computational Fluid Dynamics (ECFD VI). http://www.wccm-eccm-ecfd2014.org/admin/files/filePaper/p3774.pdf. (PDF)
    • Zhang, J., Merkle, A. C., Carneal, C. M., Armiger, R. S., Kraft, R. H., Ward, E. E., Ott, K. A., Wickwire, A. C., Dooley, C. J., Harrigan, T. P., & Roberts, J. C. (2013). Effects of torso-borne mass and loading severity on early response of the lumbar spine under high-rate vertical loading. International Research Council on Biomechanics of Injury. http://www.ircobi.org/downloads/irc13/pdf_files/19.pdf. (PDF)
    • Kraft, R. H., Dagro, A. M., McKee, P. J., Grafton, S. T., Vettel, J., McDowell, K., Vindiola, M., & Merkle, A. C. (2013). Combining the finite element method with structural network-based analysis for modeling neurotrauma. (pp. 4). 11th International Symposium, Computer Methods in Biomechanics and Biomedical Engineering. http://cmbbe13.sci.utah.edu/proceedings.html. (PDF)
    • Scheidler, M., Fitzpatrick, J., & Kraft, R. H. (2011). In Tom Proulx (Ed.), Optimal pulse shapes for SHPB tests on soft materials. 1, (pp. 259-268). Society for Experimental Mechanics Series, Dynamic Behavior of Materials. http://link.springer.com/chapter/10.1007/978-1-4614-0216-9_37. ISBN/ISSN #/Case #/DOI #: 2191-5644 (PDF)
    • Kraft, R. H., Lynch, M. L., & Vogel, E. W. (2011). Computational failure modeling of lower extremities. RTO-MP-HFM-207AC/323(HFM-207)(TP/412) . NATO Human Factors and Medicine Panel. http://www.cso.nato.int/pubs/rdp.asp?RDP=RTO-MP-HFM-207. ISBN/ISSN #/Case #/DOI #: 978-92-837-0153-8 (PDF)
    • Clayton, J. D., & Kraft, R. H. (2011) . Mesoscale modeling of dynamic failure of ceramic polycrystals. Proceedings of the 35th International Conference on Advanced Ceramics and Composites. (PDF)
    • Vettel, J. M., Bassett, D. S., Kraft, R. H., & Grafton, S. T. (2010). Physics-based models of brain structure connectivity informed by diffusion weighted imaging. 27th Army Science Conference. (PDF)
    • Gazonas, G. A., McCauley, J. W., Kraft, R. H., Love, B. M., Clayton, J. D., Casem, D., Dandekar, D., Rice, B., Batyrev, I., Weingarten, N. S., & Schuster, B. E. (2010). Multiscale modeling of armor ceramics: Focus on AlON. 27th Army Science Conference. (PDF)
    • Scheidler, M., & Kraft, R. H. (2010). In C. P. Hoppel (Ed.), Inertial effects in compression Hopkinson bar tests on soft materials. U.S. Army Research Laboratory, 1st Annual ARL Ballistic Technology Workshop. (PDF)
    • Kraft, R. H., Batyrev, I., Lee, S., Rollett, A. D., & Rice, B. (2010). In J. J. Swab, S. Mathur and T. Ohji (Eds.), "Multiscale modeling of armor ceramics." Journal of the American Ceramics Society Meeting Proceedings., 31 . Hoboken, NJ: John Wiley & Sons, Inc.. http://onlinelibrary.wiley.com/doi/10.1002/9780470944004.ch13/summary. ISBN/ISSN #/Case #/DOI #: DOI: 10.1002/9780470944004 (PDF)
    • Wereszczak, A. A., & Kraft, R. H. (2003). In W. M. Kriven and H. T. Lin (Eds.), Flexural and torsional resonances of ceramic tiles via impulse excitation of vibration. 24(4), (pp. 207-213). 27th Annual Conference on Advanced Ceramics and Composites: B: Ceramic Engineering and Science Proceedings. http://onlinelibrary.wiley.com/doi/10.1002/9780470294826.ch31/summary. ISBN/ISSN #/Case #/DOI #: DOI: 10.1002/9780470294826.ch31 (PDF)
    • Wereszczak, A. A., & Kraft, R. H. (2002). In H. T. Lin and M. Singh (Eds.), Instrumented Hertzian indentation of armor ceramics. 23(3), (pp. 11). 26th Annual Conference on Composites, Advanced Ceramics, Materials, and Structures: A: Ceramic Engineering and Science Proceedings. http://onlinelibrary.wiley.com/doi/10.1002/9780470294741.ch7/summary. ISBN/ISSN #/Case #/DOI #: DOI: 10.1002/9780470294741.ch7 (PDF)

    Book Chapters

    • Kraft, R. H., Fielding, R. A., Lister, K., Shirley, A., Marler, T., Merkle, A. C., Przekwas, A. J., Tan, X. G., & Zhou, X. (2016). Modeling skeletal injuries in military scenarios. Mechanobiology and mechanophysiology of military-related injuries Springer Berlin Heidelberg. http://link.springer.com/chapter/10.1007/8415_2016_191. (PDF)
    • Clayton, J. D., & Kraft, R. H. (2011). Mesoscale modeling of dynamic failure of ceramic polycrystals. In J. J. Swab (Ed.), Advances in Ceramic Armor VII: Ceramic Engineering and Science Proceedings. (568) . John Wiley & Sons. Peer-reviewed/refereed. http://books.google.com/books?isbn=1118173090. ISBN/ISSN #/Case #/DOI #: 1118173090, 9781118173091 (PDF)

    Technical Reports

    • Dagro, A. M., McKee, P. J., Kraft, R. H., Zhang, T. G., & Satapathy, S. S. (2013). A preliminary investigation of traumatically induced axonal injury in a three-dimensional (3-D) finite element model (FEM) of the human head during blast-loading. Army Research Laboratory Technical Report (ARL-TR-6504). http://www.ntis.gov/search/product.aspx?ABBR=ADA588181. (PDF)
    • Clayton, J. D., & Kraft, R. H. (2011). Mesoscale modeling of dynamic failure of ceramic polycrystals. Army Research Laboratory Reprint (ARL-RP-328). http://www.dtic.mil/cgi-bin/GetTRDoc?AD=ADA551733. (PDF)
    • Gozonas, G. A., McCauley, J. W., Batyrev, I. G., Casem, D., Clayton, J. D., Dandekar, D. P., Kraft, R. H., Love, B. M., Rice, B. M., Schuster, B. E., & Weingarten, N. S. (2011). Multiscale modeling of armor ceramics: Focus on AlON. Army Research Laboratory Reprint (ARL-RP-337). http://www.dtic.mil/cgi-bin/GetTRDoc?AD=ADA553163. (PDF)
    • Swab, J. J., Wereszczak, A. A., Tice, J., Caspe, R., Kraft, R. H., & Adams, J. (2005). Mechanical and thermal properties of advanced ceramics for gun barrel applications. Army Research Laboratory Technical Report (ARL-TR-3417). http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=ADA430400. (PDF)
    • Vettel, J., Dagro, A. M., Gordon, S., Kerick, S., Kraft, R. H., Luo, S., Rawal, S., Vindiola, M., & McDowell, K. (2012). Brain structure-function couplings (FY11). Army Research Laboratory Technical Report (ARL-TR-5893). http://www.dtic.mil/cgi-bin/GetTRDoc?AD=ADA556969‎. (PDF)
    • Kraft, R. H., & Wozniak, S. L. (2011). A review of computational spinal injury biomechanics research and recommendations for future efforts. Army Research Laboratory Technical Report (ARL-TR-5673). http://www.dtic.mil/cgi-bin/GetTRDoc?AD=ADA549868. (PDF)
    • Kraft, R. H., & Dagro, A. M. (2011). Design and implementation of a numerical technique to inform anisotropic hyperelastic finite element models using diffusion-weighted imaging. Army Research Laboratory Technical Report (ARL-TR-5796). http://www.dtic.mil/dtic/tr/fulltext/u2/a565877.pdf. (PDF)
    • Vettel, J. M., Bassett, D., Kraft, R. H., & Grafton, S. (2010). Physics-based models of brain structure connectivity informed by diffusion-weighted imaging. Army Research Laboratory Technical Reprint (ARL-RP-0355). Aberdeen Proving Ground, MD: U.S. Army Research Laboratory. http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=ADA552479. (PDF)
    • Wereszczak, A. A., Swab, J. J., & Kraft, R. H. (2005). Effects of machining on the uniaxial and equibiaxial flexure strength of CAP3 AD-995 Al2O3. Army Research Laboratory Technical Report (ARL-TR-3617). http://www.dtic.mil/cgi-bin/GetTRDoc?AD=ADA441313. (PDF)